SAN MATEO, Calif. and CAMBRIDGE, Mass., Aug. 08, 2024 (GLOBE NEWSWIRE) -- Kronos Bio, Inc. (Nasdaq: KRON), a company dedicated to developing small molecule therapeutics that address cancers and other diseases driven by deregulated transcription, today reported recent business progress and financial results for the second quarter of 2024.
“We continue to make great progress, both in the clinic and in expanding our pipeline targeting deregulated transcription. We are on track to share a clinical update on istisociclib in platinum-resistant high-grade serous ovarian cancer patients in the first half of 2025,” said Nobert Bischofberger, Ph.D., president and chief executive officer of Kronos Bio. “In addition, we expect to dose our first relapsed/refractory multiple myeloma patient with KB-9558 in the first half of 2025 and are excited to announce HPV-driven tumors as another potential program for KB-9558. Our collaboration with Genentech and our internal discovery programs, including a new p300 program focused on autoimmune indications, continue to advance and we look forward to sharing our progress later this year.”
Company and Pipeline Updates
Deborah Knobelman, Ph.D., appointed as chief operating officer and chief financial officer
Istisociclib (KB-0742), a CDK9 inhibitor for platinum-resistant high-grade serous ovarian cancer
KB-9558, a p300 lysine acetyltransferase (KAT) inhibitor for oncology indications
Novel p300 KAT inhibitor for autoimmune indications
Second Quarter 2024 Financial Highlights
Kronos Bio, Inc (Nasdaq: KRON) is a clinical-stage company dedicated to developing small molecule therapeutics that address deregulated transcription, a hallmark of cancer and other diseases. Our proprietary discovery engine decodes complex transcription factor regulatory networks to identify druggable cofactors. We screen for and optimize small molecules that target these cofactors in a tumor-specific context. These efforts have yielded a preclinical pipeline along with two internally developed drug candidates. Istisociclib (KB-0742) targets CDK9 to address MYC deregulation in solid tumors and KB-9558 targets p300 to address IRF4 dependence in multiple myeloma.
Kronos Bio is based in San Mateo, Calif., and has a research facility in Cambridge, Mass. For more information, visit https://www.kronosbio.com or follow the Company on LinkedIn.
Forward-Looking Statements
Statements in this press release that are not statements of historical fact are forward-looking statements for purposes of the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. The press release, in some cases, uses terms such as “anticipate,” “believe,” “could,” “expect,” “plan,” “will,” or other words that convey uncertainty of future events or outcomes to identify these forward-looking statements. Forward-looking statements include statements regarding Kronos Bio’s intentions, beliefs, projections, outlook, analyses or current expectations concerning, among other things, the timing of the next expected efficacy update for istisociclib (KB-0742) and other data and development candidate updates; the timing for the first-in-human-study of KB-5998; projected cash runway, potential programs in Kronos Bio’s pipeline; the potential of Kronos Bio’s product candidates, pipeline and its proprietary discovery engine; and other statements that are not historical fact. Actual results and the timing of events could differ materially from those anticipated in such forward-looking statements as a result of various risks and uncertainties, including, without limitation: changes in the macroeconomic environment or competitive landscape that impact Kronos Bio’s business; whether Kronos Bio will be able to progress its clinical trials on the timelines anticipated, including due to risks inherent in the clinical development of novel therapeutics; risks related to Kronos Bio’s limited experience as a company in conducting clinical trials; the risk that results of preclinical studies, early clinical trials (including preliminary results) and pharmacokinetic modeling are not necessarily predictive of future results; risks associated with enrolling clinical trials; and risks associated with the sufficiency of Kronos Bio’s cash resources and need for additional capital. These and other risks are described in greater detail in Kronos Bio’s filings with the Securities and Exchange Commission (SEC), including under the heading “Risk Factors” in its Quarterly Report on Form 10-Q for the quarter ended March 31, 2024, filed with the SEC on May 9, 2024, and in its Quarterly Report on Form 10-Q for the quarter ended June 30, 2024, being filed with the SEC later today. Any forward-looking statements that are made in this press release speak only as of the date of this press release and are based on management’s assumptions and estimates as of such date. Except as required by law, Kronos Bio assumes no obligation to update the forward-looking statements whether as a result of new information, future events or otherwise, after the date of this press release.
| Kronos Bio, Inc. Condensed Statements of Operations and Comprehensive Loss (in thousands, except per share amounts) (Unaudited) | ||||||||||||||||
| Three months ended June 30, | Six months ended June 30, | |||||||||||||||
| 2024 | 2023 | 2024 | 2023 | |||||||||||||
| Revenue | $ | 2,688 | $ | 1,864 | $ | 5,208 | $ | 3,084 | ||||||||
| Operating expenses: | ||||||||||||||||
| Research and development | $ | 13,765 | $ | 20,809 | $ | 27,987 | $ | 40,467 | ||||||||
| General and administrative | 6,368 | 10,307 | 13,874 | 20,363 | ||||||||||||
| Impairment of long-lived assets and restructuring | 578 | 2,916 | 13,364 | 2,916 | ||||||||||||
| Total operating expenses | 20,711 | 34,032 | 55,225 | 63,746 | ||||||||||||
| Loss from operations | (18,023 | ) | (32,168 | ) | (50,017 | ) | (60,662 | ) | ||||||||
| Other income (expense), net: | ||||||||||||||||
| Interest and other expense, net | 1,823 | 2427 | 3,860 | 4,683 | ||||||||||||
| Total other income (expense), net | 1,823 | 2,427 | 3,860 | 4,683 | ||||||||||||
| Net loss | $ | (16,200 | ) | $ | (29,741 | ) | (46,157 | ) | (55,979 | ) | ||||||
| Other comprehensive loss: | ||||||||||||||||
| Net unrealized loss on available-for-sale securities | 13 | (109 | ) | (55 | ) | 323 | ||||||||||
| Net comprehensive loss | $ | (16,187 | ) | $ | (29,850 | ) | $ | (46,212 | ) | $ | (55,656 | ) | ||||
| Net loss per share, basic and diluted | $ | (0.27 | ) | $ | (0.52 | ) | $ | (0.77 | ) | $ | (0.98 | ) | ||||
| Weighted average shares of common stock, basic and diluted | 60,100 | 57,398 | 59,810,229 | 57,273,284 | ||||||||||||
| Kronos Bio, Inc. Selected Balance Sheet Data (in thousands) (Unaudited) | ||||||
| June 30, 2024 | December 31, 2023 | |||||
| Cash, cash equivalents and investments | $ | 136,646 | $ | 174,986 | ||
| Total assets | 164,273 | 213,279 | ||||
| Total liabilities | 41,127 | 54,201 | ||||
| Total stockholders’ equity | 123,146 | 159,078 | ||||
| Last Trade: | US$0.90 |
| Daily Change: | 0.03 3.28 |
| Daily Volume: | 100,354 |
| Market Cap: | US$54.440M |
November 14, 2024 November 13, 2024 November 05, 2024 October 23, 2024 October 09, 2024 | |
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