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Achilles Therapeutics Reports Third Quarter 2024 Financial Results

November 14, 2024 | Last Trade: US$1.05 0.02 -1.87
  • Cash position of $86.1 million as of September 30, 2024, not including cash R&D tax credit of $12.8 million received in October 2024      

LONDON, Nov. 14, 2024 (GLOBE NEWSWIRE) -- Achilles Therapeutics plc (NASDAQ: ACHL) today announced its financial results for the third quarter ended September 30, 2024, and recent corporate updates.

Corporate Updates

  • Following the discontinuation of its TIL-based cNeT program and closure of the Phase I/IIa CHIRON and THETIS clinical trials, the Company has engaged BofA Securities as a financial advisor in the process of exploring strategic options.
  • Achilles Chief Scientific Officer, Sergio Quezada, presented “Targeting Clonal Neoantigens with Precision T-Cell Therapies: Key Mechanistic Insights From cNeT Clinical Trials” in a seminar on October 23, 2024 at the 6th Annual TIL Therapies Summit.

Financial Highlights

  • Cash and cash equivalents: Cash and cash equivalents were $86.1 million as of September 30, 2024, as compared to $131.5 million as of December 31, 2023. Subsequent to September 30, 2024, the Company received a cash R&D tax credit of $12.8 million.
  • Research and development (R&D) expenses: R&D expenses were $16.4 million for the third quarter ended September 30, 2024, compared to $14.7 million for the third quarter ended September 30, 2023.
  • General and administrative (G&A) expenses: G&A expenses were $4.0 million for the third quarter ended September 30, 2024, compared to $4.4 million for the third quarter ended September 30, 2023.
  • Net loss: Net loss for the third quarter ended September 30, 2024 was $19.6 million or $0.48 per share, compared to $16.7 million or $0.42 per share for the third quarter ended September 30, 2023.

About Achilles Therapeutics

Achilles is a clinical-stage biopharmaceutical company that was developing AI-powered precision T cell therapies targeting clonal neoantigens: protein markers unique to the individual that are expressed on the surface of every cancer cell. Achilles uses DNA sequencing data from each patient, together with its proprietary PELEUSTM bioinformatics platform, to identify clonal neoantigens specific to that patient, to enable and support development of product candidates specifically targeting those clonal neoantigens.

Forward Looking Statements

This press release contains express or implied forward-looking statements that are based on the Company management's belief and assumptions and on information currently available to the Company’s management. Forward-looking statements in this press release include, but are not limited to, statements regarding the Company’s clinical trials and the Company’s beliefs about its goals for the discontinued trials; expectations related to the Company’s cash runway and operating expenses and capital expense requirements; the Company’s ability to engage with third parties who are developing alternative modalities to target clonal neoantigens for the treatment of cancers and the Company’s review and evaluation of potential strategic options and their impact on stockholder value. Although the Company believes that the expectations reflected in these forward-looking statements are reasonable, these statements relate to future events or the Company’s future operational or financial performance, and involve known and unknown risks, uncertainties and other factors that may cause the Company’s actual results, performance, or achievements to be materially different from any future results, performance or achievements expressed or implied by these forward-looking statements. The forward-looking statements in this press release represent the Company’s views as of the date of this press release. We anticipate that subsequent events and developments will cause the Company’s views to change. However, while the Company may elect to update these forward-looking statements at some point in the future, the Company has no current intention of doing so except to the extent required by applicable law. You should therefore not rely on these forward-looking statements as representing the Company’s views as of any date subsequent to the date of this press release.

For further information, please contact:

Meru Advisors
Lee M. Stern
This email address is being protected from spambots. You need JavaScript enabled to view it.

 
 
ACHILLES THERAPEUTICS PLC
Condensed Consolidated Balance Sheets (Unaudited)
(in thousands, except share and per share amounts)
(expressed in U.S. Dollars, unless otherwise stated)
 
      September 30,  December 31,
  2024   2023 
ASSETS   
CURRENT ASSETS:   
Cash and cash equivalents$86,052  $131,539 
Prepaid expenses and other current assets 25,573   14,094 
Total current assets 111,625   145,633 
Property and equipment, net 5,827   9,171 
Operating lease right of use assets 3,407   4,372 
Deferred tax assets 41   41 
Restricted cash 20   33 
Other assets 1,756   2,206 
Total non-current assets 11,051   15,823 
Total assets$122,676  $161,456 
LIABILITIES AND SHAREHOLDERS’ EQUITY   
CURRENT LIABILITIES:   
Accounts payable$   4,248  $5,629 
Accrued expenses and other liabilities                        10,602   7,828 
Operating lease liabilities - current 3,620   3,539 
Total current liabilities                     18,470   16,996 
NON-CURRENT LIABILITIES:   
Operating lease liabilities - non-current -   1,076 
Other long-term liability 1,068   1,015 
Total non-current liabilities 1,068   2,091 
Total liabilities                     19,538   19,087 
    
Commitments and contingencies   
SHAREHOLDERS’ EQUITY:   
Ordinary shares, £0.001 par value; 41,100,040 and 41,082,948 shares authorized, issued and outstanding at September 30, 2024 and December 31, 2023, respectively 54   54 
Deferred shares, £92,451.85. par value, one share authorized, issued and outstanding at September 30, 2024 and December 31, 2023, respectively 128   128 
Additional paid in capital 419,098   415,210 
Accumulated other comprehensive income (7,941)  (13,071)
Accumulated deficit (308,201)  (259,952)
Total shareholders’ equity                  103,138   142,369 
TOTAL LIABILITIES AND SHAREHOLDERS’ EQUITY$122,676  $161,456 

 

 
ACHILLES THERAPEUTICS PLC

Condensed Consolidated Statements of Operations and Comprehensive Loss (Unaudited)
(in thousands, except share and per share amounts)
(expressed in U.S. Dollars, unless otherwise stated)
 
   Three Months Ended   Nine Months Ended
   September 30,   September 30,
   2024   2023   2024   2023 
OPERATING EXPENSES:       
 Research and development$16,396  $14,712  $40,171  $42,354 
 General and administrative                  4,021   4,384  $12,344   13,387 
 Total operating expenses               20,417   19,096                 52,515   55,741 
LOSS FROM OPERATIONS: (20,417)  (19,096)  (52,515)  (55,741)
OTHER INCOME (EXPENSE), NET:       
 Other income (expense) 817   2,389   4,246   4,692 
 Total other income (expense), net 817   2,389   4,246   4,692 
Loss before income taxes (19,600)  (16,707)  (48,269)  (51,049)
 Benefit for income taxes 5   24                         20   14 
Net loss  (19,595)  (16,683)  (48,249)  (51,035)
Other comprehensive (loss) income:       
 Foreign exchange translation adjustment 6,074   (5,289)  5,130   2,505 
Comprehensive loss$(13,521) $(21,972) $(43,119) $(48,530)
Net loss per share attributable to ordinary shareholders—basic and diluted$(0.48) $(0.42) $(1.20) $(1.28)
Weighted average ordinary shares outstanding—basic and diluted 40,427,199   40,066,922   40,355,124   39,900,910 
 

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