WILMINGTON, Mass. / Apr 10, 2023 / Business Wire / Charles River Laboratories International, Inc. (NYSE: CRL) today announced that its team of oncology experts will attend the American Association for Cancer Research (AACR) Annual Meeting, with 19 scientific posters and a spotlight presentation to highlight its enhanced oncology portfolio. The meeting is taking place from April 14-19, 2023, at the Orange County Convention Center in Orlando, Florida, with Charles River at Booth #943.
Charles River’s team of industry-leading oncology experts have contributed to 84 percent of the cancer therapies approved by the Food and Drug Administration from 2018-2022. Additionally, Charles River has been named as co-inventors on 78 patents, and supported 16 clinical candidates and 11 FDA-approved cell and gene therapies. At the AACR Annual Meeting, researchers will present recent work utilizing emerging tools and approaches for cancer research.
Navigating Cell Therapy Discovery and Development
Cell therapies continue to be a focus in the field of advanced therapies. During a Spotlight Session, scientific leaders from across disciplines will discuss cell therapy discovery and development, including insights into the discovery journey from materials, research models, and quality assessment, as well as considerations and capabilities to streamline research and mitigate self-inflicted risks.
Utilizing Technology to Fuel Discovery Innovation
Mutation-targeting therapies have become a new paradigm for cancer treatment. In a joint poster presentation, Charles River and Cypre, Inc. will present the use of 3D in vitro tumor panels, that include a hydrogel matrix and fibroblasts to replicate the stromal compartment of the tumor microenvironment to test mutation-targeting therapies. The strategic partnership between Charles River and Cypre provides clients with access to Cypre’s proprietary 3D hydrogel patterning technology – Symphony® and VersaGel® – to predict therapeutic efficacy of targeted and immuno-oncology agents in a more representative and high throughput model of the tumor microenvironment. The models incorporate patient-derived xenografts (PDX) from Charles River’s Cancer Model Database, enabling a seamless transition to in vivo studies following indication and model selection.
Identifying how to optimally combine immunotherapies with other available anti-cancer therapies is a major challenge in oncology. In February 2021, Charles River announced a strategic partnership with Kibur Medical to offer exclusive access to its implantable microdevice (IMD) for in vivo preclinical oncology studies. Now, in a joint poster presentation, Charles River and Kibur Medical highlight the use of an implantable microdevice that allows cassette microdosing and measurement of intratumor drug responses and anti-tumor immunity for up to 20 different agents in parallel.
Lastly, the increased use of machine learning (ML) in drug discovery has allowed medicinal chemists to operate at a vastly different scale than traditional approaches by enabling them to search much larger universes of potential compounds. In 2022, Charles River and Valo Health launched LogicaTM, an artificial intelligence (AI) powered solution that directly translates clients’ biological insights into optimized preclinical assets. Experts from the Logica team will be available at the Charles River Booth #943 to discuss the unique risk-sharing model of Logica that ties costs to value generation points.
A full schedule of Charles River’s activities during AACR 2023, as well was reprints of each poster, are available online. Charles River experts will be available for meetings to discuss how an integrated approach can support drug discovery and development programs from hit identification to IND (Investigational New Drug) filing.
Throughout the conference, Charles River will be providing live updates on the Eureka Blog, including reviews of scientific sessions and input on the research being presented.
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About Charles River
Charles River provides essential products and services to help pharmaceutical and biotechnology companies, government agencies and leading academic institutions around the globe accelerate their research and drug development efforts. Our dedicated employees are focused on providing clients with exactly what they need to improve and expedite the discovery, early-stage development and safe manufacture of new therapies for the patients who need them. To learn more about our unique portfolio and breadth of services, visit www.criver.com.
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