• CRB-913 is a novel oral cannabinoid type 1 receptor (CB1) inverse agonist with potent pre-clinical anti-obesity activity
• CRB-913 markedly enhances pre-clinical efficacy of liraglutide, semaglutide, and tirzepatide
• CB1 inverse agonism is a clinically validated therapeutic approach to treating obesity

Corbus Pharmaceuticals Holdings, Inc. (NASDAQ: CRBP) ("Corbus" or the "Company"), an immunology company, announced that preclinical data for CRB-913 are being presented today in an oral presentation at the European Association for the Study of Diabetes 2022 Annual Conference taking place in Stockholm, Sweden. 

The data show that in the diet-induced obesity (DIO) mouse model, CRB-913 monotherapy demonstrated a reduction in body weight, body fat content, food consumption, liver triglycerides, and liver fat deposits as well as improvements in insulin resistance and leptinemia. Combining CRB-913 with the incretin analogues liraglutide, semaglutide, or tirzepatide demonstrated significant additive effects across all these outcomes.

"The data presented today are exciting as they demonstrate that CRB-913 is a differentiated CB1 inverse agonist with improved pharmacokinetic properties compared to the first generation of these drugs while still retaining the same efficacy," commented Rachael Brake, Ph.D., Chief Scientific Officer of Corbus. "Furthermore, potentially combining CRB-913 with an incretin analogue into a single therapy could meaningfully enhance the current standard of care as well as expand the number of patients who could benefit from anti-obesity drug therapy."

The EASD presentation is available on the company's website at: 58^th European Association for the Study of Diabetes (EASD) presentation on CRB-913 (CB1 Inverse Agonist).

Corbus is an immunology company committed to helping people defeat serious illness by bringing innovative scientific approaches to well understood biological pathways. Corbus' current pipeline includes anti-integrin monoclonal antibodies that block activation of TGFβ and small molecules that activate or inhibit the endocannabinoid system. Corbus is headquartered in Norwood, Massachusetts. For more information on Corbus, visit corbuspharma.com and connect on Twitter, LinkedIn, and Facebook.

This press release contains certain forward-looking statements within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934 and Private Securities Litigation Reform Act, as amended, including those relating to the Company's restructuring, trial results, product development, clinical and regulatory timelines, market opportunity, competitive position, possible or assumed future results of operations, business strategies, potential growth opportunities and other statement that are predictive in nature. These forward-looking statements are based on current expectations, estimates, forecasts and projections about the industry and markets in which we operate and management's current beliefs and assumptions.

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